Investigating injectability of high concentration mAb formulations with VROC technology

Investigating injectability of high concentration mAb formulations with VROC technology

Thursday, September 18, 2025 10:40 AM to 11:10 AM · 30 min. (Europe/Zurich)
Speakers Corner
Ilmac Basel
Ilmac Basel

Information

In this presentation, we explore the critical role of viscosity in developing high-concentration monoclonal antibody (mAb) formulations (≥ 100 mg/mL) for subcutaneous injection.

To improve patient experience and compliance, these biotherapeutics must be suitable for injectability, which must further be explored by measuring their non-Newtonian behavior at representative shear rates during injection.

We demonstrate the use of RheoSense VROC technology for the accurate screening of formulation candidates using small sample volumes (< 200 µL). By generating comprehensive viscosity profiles over a wide shear rate range, this method allows for the effective identification and selection of viable candidates with optimal viscosity for subcutaneous delivery, ensuring proper therapeutic development.

Speaker:

  • Dr. Dana Kauerhof, Application Scientist II, Sphera Analytics GmbH
  • Dr. Chrystian Ochoa, Application Scientist II, RheoSense Inc.

Ilmac Highlights
Speakers Corner
Sphera Analytics GmbHA120Sphera Analytics GmbH is a leading provider of innovative and customer-oriented analytical equipment designed for quality control, development, and production across diverse industries. Our cutting-edge solutions, combined with comprehensive testing services, help businesses and researchers achieve accurate, reliable results to optimize their processes and drive success in their projects. We specialize in supplying non-destructive, contact-free instruments that are fully automated and suitable for a wide range of applications. Microfluidic Rheometers & Viscometers: With exceptionally wide shear and viscosity ranges, these instruments provide accurate flow behavior and viscosity measurements for both small and large samples, essential for pharmaceuticals, biotechnology, materials science, ink manufacturing, battery production, etc. Raman Spectrometers: Offering non-destructive chemical analysis, these spectrometers enable you to perform detailed molecular and structural analysis of your samples, providing key insights for materials science, pharmaceuticals, and chemical manufacturing. Nano Particle Size & Zeta Potential Analyzers: Perfect for measuring the size distribution and surface charge of nanoparticles, ensuring the stability and performance of formulations in sectors like nanotechnology, biotechnology, and pharmaceuticals. Surface Tension & Contact Angle Instruments: Measure the wettability and adhesion properties of materials, essential for coatings, packaging, and adhesive testing. Mechanical Testers for Viscoelastic Properties: Evaluate the elasticity and viscosity of materials, crucial for understanding the mechanical performance of products in biomedicine, polymers, and coatings. Turbidity Meters & Nephelometers: Used for suspension clarity and particle concentration measurements, providing essential data for water quality testing, pharmaceuticals, and food production. Coagulation Testers: Analyzing milk coagulation and crucial for cheese production. At Sphera Analytics GmbH, we don’t just supply world-class analytical instruments; we provide expertise, insights, and tailored solutions that empower our clients to succeed. By combining cutting-edge technology with deep scientific knowledge, we ensure our solutions help you achieve your goals and drive innovation. Whether you’re looking to optimize your product development, ensure quality control, or conduct groundbreaking research, Sphera Analytics is your trusted partner in precision measurement and material analysis.

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